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. 2014 Apr 7;592(Pt 13):2771–2783. doi: 10.1113/jphysiol.2014.272864

Figure 5. Calcium chelation in astrocytes attenuates nearby synaptic transmission.

Figure 5

A, OGB-1-loaded CA3 cells and astrocytes co-loaded with BAPTA and Alexa 594-dextran were confocally imaged and merged in the right panel. The region in the white square is magnified in the right inset. B, dual whole-cell recordings were obtained from a synaptically coupled pair of CA3 pyramidal cells. Averaged unitary postsynaptic currents triggered by single presynaptic spikes were recorded before and after intracellular BAPTA injection. C, the amplitudes of the postsynaptic currents were normalized to the baseline level before BAPTA infusion and plotted as a function of time relative to the BAPTA injection (n = 4 cells). Error bars are SEM.