Table 1.

Parameters characterizing decline of ERP with successive flashes

Parameter	A	B	PA	PB
Liquid light guide (WT)	0.85 ± 0.05	0.15 ± 0.12	0.71 ± 0.02	0.08 ± 0.02
Liquid light guide (Opn1sw−/−)	0.90 ± 0.03	0.10 ± 0.16	0.71 ± 0.01	0.10 ± 0.01
Glass fibre optic (WT)	0.79 ± 0.02	0.21 ± 0.02	0.40 ± 0.05	0.02 ± 0.003

A and B represent complementary fractions of the initial ERP amplitude which are depleted at the rates P_A and P_B, respectively, by successive unattenuated flashes delivered via either the liquid light guide or the glass fibre optic (Methods) to the dark-adapted eye at 30 Hz (eqn (5)). The parameter values for the liquid guide were estimated from the WT data of Fig. 3B (n = 5), while those for the glass fibre optic were obtained from analysis of a randomly selected subset (n = 16) from 160 experiments. The error terms in the table are SEMs. The average fraction bleached by a single flash to the dark-adapted eye or in a steady-state level of regeneration was estimated as f_B = (A × P_A) + (B × P_B).