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. 2014 May 16;592(Pt 13):2813–2827. doi: 10.1113/jphysiol.2014.270793

Figure 9. Transient activation of NMDARs potentiates subsequently evoked firing activity.

Figure 9

A, sample of repetitive firing activity evoked before and after transient activation of NMDA receptors (20 μm, 3.5 s) in an MNC. Iinj: current injected. B, the evoked firing for the periods 1 and 2 and 3 from panel A are shown at an expanded time scale. Note the shorter delay to the first evoked spike during the second depolarization (2) and the partial recovery during the third depolarization (3). C, plot of mean percentage changes in the evoked number of spikes following transient NMDAR activation (n = 17). *P < 0.001 vs. basal depolarization; #P < 0.01 vs. 7.5 s (Bonferroni's post hoc test).