Figure 5.

Representative photomicrographs of kidney sections from rats treated with BVEE and gentamicin (H&E staining). Light microscopic examination (×20 objective lens) of kidney tissue. (a) Normal kidney section; (b) effect of gentamicin on kidney tissue showing tubular degeneration, massive necrosis, and focal interstitial nephritis made up of lymphocytes and plasma cells, desquamation of renal tubule epithelium, and vacuolization; (c) effect of BVEE 250 mg/kg, pretreatment showing absence of interstitial nephritis and improvement degree of renal tubule changes; (d) effect of BVEE 500 mg/kg, pretreatment showing almost normal tubules, interstitial, and glomeruli.