Figure 6.

Comparison of gene expression of PHDFs cultured on BMSF scaffolds of varying fiber diameter. The differences in relative gene expression between PHDFs cultured on increasing fiber diameter show a decrease in collagen I and collagen III expression with increasing fiber size. PCNA expression increased in nanofibrous scaffolds (**p < 0.001). There were significant differences between smaller diameter fibers and larger fibers at day 3 but comparable levels of FAK after 7 Days of culture (**p < 0.001). Values are means of three independent experiments performed in triplicate with three different PHDF populations.

PHDF: primary human dermal fibroblast; BMSF: Bombyx mori silk fibroin; PCNA: proliferating cell nuclear antigen.