Table 2.
List of nonconserved residues in HCV NS3 genotype 3a structure in comparison with other HCV NS3 genotypes. Bold residues were seen shared among templates and models.
| Position of the residue | Crystal structures | Model of NS3 GT3a | ||
|---|---|---|---|---|
| Residue | Interactions | Residue | Interactions | |
| 219 | ALA | — | VAL | VAL225, ILE248, LEU265 |
|
| ||||
| 224 | LYS | ALA283, ASP285 | ASN | ASP285 |
|
| ||||
| 286 | ILE | LEU317, VAL319 | VAL | LEU317, VAL319 |
|
| ||||
| 297 | SER | GLU493 | ALA | — |
|
| ||||
| 315 | ALA | — | VAL | ILE285 |
|
| ||||
| 354 | ILE | ILE359, ILE366, ILE426 | LEU | LEU341, ILE426, PHE349, LEU358 |
|
| ||||
| 358 | THR | — | LEU | LEU358 |
|
| ||||
| 377 | LEU | LEU381, VAL409 | ILE | LEU381 |
|
| ||||
| 384 | LEU | — | MET | ILE345 |
|
| ||||
| 407 | ILE | — | VAL | ILE357, ILE364, LEU379 |
|
| ||||
| 430 | THR | ARG461 | VAL | ARG461 |
|
| ||||
| 433 | THR | — | GLU | ARG479 |
|
| ||||
| 445 | THR | — | SER | SER439 |
|
| ||||
| 477 | THR | — | SER | ASN429, ARG458 |
|
| ||||
| 489 | SER | — | VAL | PHE557, VAL436, ILE446 |
|
| ||||
| 500 | ALA | LYS551 | SER | ASP496 |
|
| ||||
| 505 | THR | — | GLN | THR509 |
|
| ||||
| 510 | SER | GLU533 | THR | — |
|
| ||||
| 530 | GLU | — | ASP | SER534 |
|
| ||||
| 553 | ALA | — | GLN | LYS583 |
|
| ||||
| 561 | VAL | MET581, TRP582, LEU602 | THR | PHE557 |
|
| ||||
| 605 | VAL | VAL609 | ILE | VAL609, LEU598 |