Table 2.

Authors	Patient (Age, sex)	Localization	Chemotherapy	Symptoms	MRI	Treatment	Outcomes
Matsunaga et al., 2012 [30]	43 W	Metastatic sigmoid cancer	Modified Folfox 6	Nausea, headache, disturbed consciousness, visual disturbance, seizures Status epilepticus hypertension	Bilateral occipital lesions on MRI	No medication for hypertension	No neurologic sequelae MRI brain resolved 40 days later
Nagata et al., 2009 [31]	35 W	Metastatic sigmoid	Folfox regimen	Convulsions, headache, and visual disturbance hypertension	Bilateral lesions on posterior lobes on MRI	Antihypertensive therapy and anticonvulsive therapy	Complete resolution of symptoms MRI changes resolved 30 days later
Sharief and Perry, 2009 [32]	59 M	Metastatic colon cancer	Folfox 6 regimen	Status epilepticus BP: 156/98	Bilateral frontal cortical lesion on MRI noncontrast CT scan of the head was normal	Seizure medications	Complete recovery in 24 h MRI brain resolved two weeks later
Pinedo et al., 2007 [33]	62 W	Metastatic adenocarcinoma of rectum	Folfox + Bevacizumab	Seizures, altered mental status, bilateral lower extremity weakness BP: 190/88	Lesions on posterior lobes on MRI	Diazepam	Complete resolution on MRI 10 days later
Skelton et al., 2007 [34]	1 F	Metastatic adenocarcinoma of rectum	Folfox	Seizures Altered mental status	Hyperintensity in the white matter of the posterior hemispheres		Resolution of lesion on repeated MRI