Table 2. Changes in Biochemical and Anthropometric Data in the Simvastatin- and Placebo-Treated Groups a,b,c.
| Study Groups (n = 51) | First Pretreatment | Post-treatment Period | Second Pretreatment | Post-treatment Period | Period effect | Treatment effect (S vs. P) |
|---|---|---|---|---|---|---|
| FBG, mg/dL | (P > 0.05) | (P > 0.05) | ||||
| Statin-placebo | 86.46 ± 19.52 | 85.58 ± 17.12 | 81.28 ± 15.83 | 81.09 ± 13.65 | ||
| Placebo-statin | 104.36 ± 47.61 | 101.71 ± 45.86 | 103.5 ± 45.55 | 99.10 ± 33.28 | ||
| Weight, kg | (P < 0.01) | (P > 0.05) | ||||
| Statin-placebo | 71.59 ± 22.02 | 72.42 ± 19.24 | 73.80 ± 18.60 | 75.27 ± 18.55 | ||
| Placebo-statin | 78.04 ± 16.63 | 77.17 ± 16.30 | 76.99 ± 15.50 | 76.71 ± 16.41 | ||
| BMI, kg/m 2 | (P < 0.05) | (P > 0.05) | ||||
| Statin-placebo | 28.83 ± 6.18 | 28.30 ± 6.19 | 28.95 ± 5.90 | 29.09 ± 5.91 | ||
| Placebo-statin | 31.12 ± 6.41 | 30.83 ± 6.36 | 30.33 ± 7.41 | 31.25 ± 6.04 | ||
| TC, mg/dL | (P > 0.05) | (P < 0.001) | ||||
| Statin-placebo | 203.02 ± 36.11 | 152.48 ± 41.60 | 181.69 ± 30.65 | 182.38 ± 37.64 | ||
| Placebo-statin | 193.32 ± 39.65 | 191.06 ± 38.04 | 194.85 ± 37.75 | 160.37 ± 60.81 | ||
| LDLc, mg/dL | (P > 0.05) | (P < 0.001) | ||||
| Statin-placebo | 131.44 ± 28.46 | 87.35 ± 35.01 | 119.75 ± 26.44 | 121.09 ± 23.86 | ||
| Placebo-statin | 118.38 ± 30.48 | 115.22 ± 35.03 | 121.75 ± 28.25 | 92.50 ± 46.48 | ||
| HDLc, mg/dL | (P > 0.05) | (P > 0.05) | ||||
| Statin-placebo | 44.08 ± 10.80 | 43.31 ± 12.19 | 40.36 ± 13.34 | 41.79 ± 14.97 | ||
| Placebo-statin | 42.40 ± 11.92 | 42.64 ± 13.32 | 44.55 ± 12.42 | 45.96 ± 14.58 | ||
| TG, mg/dL | (P > 0.05) | (P < 0.001) | ||||
| Statin-placebo | 1.325 (1.00, 2.0) | 1.25 (91.5, 2.2) | 1.225 (87.5, 1.90) | 1.05 (80.25, 1.56) | ||
| Placebo-statin | 1.24 (93.00, 1.73) | 1.12 (73.0, 1.5) | 1.250 (82.0, 1.77) | 1.14 (90.00, 1.53) | ||
| APN, ng/mL | (P > 0.05) | (P > 0.05) | ||||
| Statin-placebo | 0.56 ± 0.29 | 0.63 ± 0.29 | 0.73± 0.32 | 0.59 ± 0.28 | ||
| Placebo-statin | 0.55± 0.33 | 0.63 ± 0.32 | 0.63 ± 0.32 | 0.56 ± 0.27 |
a Abbreviations: BMI body mass index; FBS, fasting blood sugar; TC, total cholesterol; HDL, high-density lipoprotein; LDL, low-density lipoprotein; TG, triglycerides; APN, adiponectin.
b Values are expressed as means ± SD for normally distributed data and median and interquartile range. Statin-placebo group took statin at first, while placebo-statin group received statin following placebo.
c Defined as comparison of mean values between the first and second periods.