Table 2.
PK parameters for each patient
| Patient | C max (μg/mL) | C min (μg/mL) | VD (L/kg) | Ke (h –1 ) | CL (L/h) | t 1/2 (h) | AUC [0-inf] | Dose in mg/kg |
|---|---|---|---|---|---|---|---|---|
| 1 |
283.97 |
13.29 |
0.26 |
0.53 |
7.45 |
1.31 |
398.78 |
54.05 |
| 2 |
200.56 |
16.87 |
0.35 |
0.44 |
8.70 |
1.59 |
419.14 |
52.63 |
| 4 |
337.21 |
6.36 |
0.22 |
0.69 |
8.15 |
1.01 |
232.15 |
70.18 |
| 5 |
211.53 |
18.76 |
0.35 |
0.43 |
8.19 |
1.60 |
446.61 |
46.51 |
| 6 |
153.13 |
18.74 |
0.61 |
0.36 |
9.30 |
1.95 |
311.08 |
85.11 |
| 7 |
97.37 |
3.88 |
0.52 |
0.57 |
23.54 |
1.21 |
163.28 |
63.49 |
| 8 |
94.10 |
2.22 |
0.65 |
0.64 |
27.25 |
1.08 |
115.12 |
58.82 |
| 10 |
465.78 |
13.64 |
0.15 |
0.57 |
4.93 |
1.21 |
607.15 |
86.96 |
| 11 |
162.34 |
5.18 |
0.42 |
0.53 |
13.13 |
1.30 |
317.32 |
66.67 |
| 12 |
179.52 |
37.65 |
0.45 |
0.26 |
5.84 |
2.65 |
418.48 |
60.61 |
| 13 |
318.81 |
28.34 |
0.26 |
0.44 |
5.48 |
1.59 |
667.45 |
62.50 |
| 14 |
319.55 |
19.07 |
0.30 |
0.50 |
6.20 |
1.40 |
477.15 |
78.43 |
| 15 |
513.74 |
4.52 |
0.10 |
0.82 |
6.38 |
0.85 |
678.99 |
86.96 |
| 16 |
1133 |
0.47 |
0.08 |
1.25 |
4.42 |
0.55 |
827.16 |
66.67 |
|
Mean |
319.33 |
13.50 |
0.34 |
0.57 |
9.93 |
1.38 |
434.28 |
67.11 |
| σ(n-1) | 266.08 | 10.71 | 0.18 | 0.24 | 6.95 | 0.51 | 205.17 | 13.01 |
Mentioned on page 6.