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. 2014 Nov 6;8:372. doi: 10.3389/fncel.2014.00372

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Copyright © 2014 Sun, Zhang, Sun, Nair, Petrus and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Altered dendritic morphology in KIV^–/– mice. (A) Photomicrograph of a pair of neurobiotin labeled spiny stellate cells from littermate wild-type (A1,A3) and KIV^-/- mice (A2,A4), respectively. Scale bar in (A1,A2) 10 μm; Scale bar in (A3,A4) 2 μm. White arrows in (A3,A4) dendritic spines. (B) Sholl analysis was performed to compare the distribution of dendritic spines (B1), the distribution of total dendritic length (B2), as well as the no. of intersections (B3) along different dendritic radiums from the soma. (B4) The average no. of dendritic spines was plotted against its dendritic length in wild-type mice (black squares) and KIV^-/^- mice (red circles). (B5) the spine density in wild-type vs. KIV^-/^- mice was plotted against the dendritic radius from the soma. n= 25 and 19 wild-type and mutant spiny stellate cells, respectively.