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. 2014 Nov 6;5:529. doi: 10.3389/fimmu.2014.00529

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Copyright © 2014 Jameson-Lee, Koparde, Griffith, Scalora, Sampson, Khalid, Sheth, Batalo, Serrano, Roberts, Hess, Buck, Neale, Manjili and Toor.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Whole exome sequence variation and resulting HLA-binding oligopeptides in MRD and URD. (A) Number of nsSNP, and the resulting presented (IC50 < 500 nM) and strongly presented (IC50 < 50 nM) peptides (GVH vector) presented by the HLA in each patient. (B) Same data as in (A), presented with the y-axis changed to log-scale to better illustrate the SNP to HLA-binding peptide ratio between MRD and URD. Significant difference observed in the distribution of SMM-IEDB predicted presented and strongly presented peptides between MRD and URD. Patients 2, 4, 16, 23 – MRD; patients 3, 5, 7, 8, 10 – URD SCT recipients.