Table 3.

Number of presented and strongly presented peptides predicted by the IEDB SMM and NetMHCpan algorithms.

Donor–recipient pair	Number of nsSNPGVH	SMM presented peptide-HLA	SMM strongly presented peptide-HLA	NetMHC presented peptide-HLA	NetMHC strongly presented peptide-HLA	Shared presented peptide-HLA
2	4,446	1,926	250	3,883	1,376	1,332
4	4,448	5,412	825	3,962	885	2,441
16	3,290	2,111	177	1,071	427	417
23	3,657	13,456	705	787	118	534
3	7,227	72,294	21,339	7,242	2,509	4,881
5	6,572	30,730	2,254	2,759	538	1,865
7	6,725	58,209	21,548	5,231	2,178	2,931
8	6,573	65,298	19,275	4,831	2,000	2,445
10	9,203	18,396	2,283	5,002	989	2,065

The number of unique peptide-HLA complexes identified in silico for each donor-recipient pair. Last column represents number of unique peptides predicted to bind the relevant HLA by both algorithms. Unrelated DRP are shaded gray. Presented (intermediate affinity HLA binding) and strongly presented (strong affinity HLA binding) peptide-HLA complexes have IC50 of <500 and <50 nM, respectively.