Table 1.

Summary of GWAS results from IgAN and membranous nephropathy cohorts

Study	Cohort	dbSNP locus	Locus			P value	Odds ratio (95% CI) per allele
			Chromosome	Minor allele	Nearest gene
Yu et al. (2012)27	4,137 Han Chinese patients with IgAN and 7,734 population controls	rs2738048	8	A	DEFAs	3.18×10−14	0.79 (0.74–0.84)
		rs3803800	17	G	TNFSF13	9.40×10−11	1.21 (1.14–1.28)
		rs4227	17	T	MPDU1	4.31×10−10	1.23 (1.16–1.32)
		rs12537	22	C	MTMR3	1.17×10−11	0.78 (0.72–0.84)
		rs2523946	6	T	HLA-A	1.74×10−11	1.21 (1.15–1.28)
		rs660895	6	A	HLA-DRB1	4.13×10−20	1.34 (1.26–1.42)
		rs1794275	6	G	HLA-DQA/B	3.43×10−13	1.30 (1.21–1.39)
Feehally et al. (2010)25	244 European patients with IgAN and 4,980 population controls	rs3115573	6	A	NLNHP4	2.00×10−6	1.55 (1.29–1.85)
		rs3130315	6	G	NLNHP4	2.00×10−6	1.55 (1.29–1.85)
Gharavi et al. (2011)26	3,144 Han Chinese patients with IgAN and 2,822 population controls*	rs3766404	1	C	CFHR1,3	4.24×10−5	0.77
		rs6677604	1	A	CFHR1,3	2.96×10−10	0.68
		rs2856717	6	T	HLA-DQB1	8.44×10−16	0.73
		rs9275596	6	C	HLA-DQB1	1.59×10−26	0.63
		rs9357155	6	A	PSMB8	2.11×10−12	0.71
		rs2071543	6	A	PSMB8	5.77×10−12	0.73
		rs1883414	6	T	HLA-DPB2	4.84×10−9	0.78
		rs3129269	6	T	HLA-DPB2	8.54×10−9	0.79
		rs2412971	22	A	HORMAD2	1.86×10−9	0.80
		rs2412973	22	A	HORMAD2	4.46×10−9	0.80
Stanescu et al. (2011)51	556 white European patients with membranous nephropathy and 2,338 population controls	rs4664308	2	A	PLA2R1	8.6×10−29	2.28 (1.96–2.64)
		rs2187668	6	G	HLA-DQA1	8.0×10−93	4.32 (3.73–5.01)

^*All values are given for the Beijing discovery cohort, plus both the Shanghai and European replication cohorts, combined. Abbreviations: dbSNP, database of single nucleotide polymorphisms; GWAS, genome-wide association study; IgAN, IgA nephropathy.