Table 3.

Inclusion and exclusion criteria: definitions

Event	Definition
Pancreatic necrosis	Diffuse or focal area(s) of non-enhancing pancreatic parenchyma as detected on contrast enhanced CT (CECT)
Extrapancreatic necrosis	Persistent peripancreatic fluid collections on CECT in the absence of pancreatic parenchymal non-enhancement
(Suspected) infected necrosis	• Infected necrosis is defined as a positive culture of pancreatic necrosis or extrapancreatic necrosis obtained by fine-needle aspiration (FNA) or the presence of gas in the fluid collection on CECT.
	• Suspected infected necrosis is defined as persistent sepsis or progressive clinical deterioration despite maximal support on the intensive care unit (ICU) in case of pancreatic necrosis or extrapancreatic necrosis, without documentation of infected necrosis and without other causes for infection
Previous intervention	Previous exploratory laparotomy for suspected abdominal compartment syndrome, bleeding or suspected bowel perforation is only allowed if the omental bursa was not opened
MODS	The Multiple Organ Dysfunction Score (MODS) ranges from 0 to 24, with higher scores indicating more severe organ dysfunction
SOFA	Scores on the Sequential Organ Failure Assessment (SOFA) scale range from 0 to 24, with higher scores indicating more severe organ dysfunction