Figure 4.

Results of OCT. Left, OCT of the vehicle-injected and PGJ₂-treated eyes of animal E4 at baseline and at 1 day, 1 week, and 4 weeks post pNAION induction. Note that there is considerably more intraretinal and subretinal swelling at both 1 day and 1 week post pNAION in the vehicle-injected eye than in the PGJ₂-treated eye (asterisks) and that there is better preservation of the retinal architecture in the PGJ₂-treated eye than in the vehicle-injected eye at 4 weeks post pNAION induction. Right, PRNFL thickness for each animal (n = 4) and for the group as a whole at baseline (hatched bars) and 1 month post pNAION induction followed by IVT injection of either PGJ₂ (black bars) or vehicle (white bars). (Vehicle versus baseline: P = 0.06; PGJ₂ versus baseline: P = 0.63; PGJ₂ versus vehicle: P = 0.03, Wilcoxon Rank Sum Test.) Error bars are ±1 SD except for composite, which is ±1 SE.