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. 2013 Nov 22;12:173. doi: 10.1186/1475-2840-12-173

Table 1.

Anthropometric data, blood chemistry and lipoprotein metabolism data in healthy participants with low plasma HDL-C vs. high plasma HDL-C concentration

  Low HDL High HDL P
Gender
 21 men/16 women
 20 men/16 women
  
Age (year)
 37 ± 11
 45 ± 14
 0.022
BMI (Kg/m2)
 24.0 ± 2.4
 23.5 ± 3.3
  
Waist (cm)
 80 ± 9
 80 ± 9
  
Glucose (mg/dL)
 83 ± 8
 84 ± 8
  
Insulin (μU/mL)
 6.5 ± 3.1
 4.4 ± 1.8
 <0.001
HOMA index
 1.35 ± 0.67
 0.91 ± 0.39
 0.001
Triglycerides (mg/dL)
 97 ± 33
 71 ± 34
 0.002
Cholesterol (mg/dL)
 159 ± 25
 186 ± 30
 <0.001
HDL-C (mg/dL)
 34 ± 4
 79 ± 13
 <0.001
LDL-C (mg/dL)
 106 ± 22
 93 ± 22
 0.018
VLDL (mg/dL)
 19 ± 7
 14 ± 7
 0.001
TG/HDL ratio
 3.00 ± 1.32
 0.91 ± 0.42
 <0.001
Apo AI (mg/dL)
 84.8 ± 15.5
 124.9 ± 19.4
 <0.001
Apo B (mg/dL)
 75.4 ± 21.7
 71.8 ± 17.1
  
Apo CII (mg/dL)
 3.1 ± 1.9
 3.1 ± 1.5
  
Apo CIII (mg/dL)
 7.3 ± 3.1
 6.7 ± 4.4
  
Apo E (mg/dL)
 2.1 ± 0.8
 3.2 ± 1.2
 <0.001
ALT (U/L)
 24 ± 16
 16 ± 5
 0.005
AST (U/L)
 20 ± 6
 19 ± 3
  
hsCRP (mg/L)
 1.7 ± 2.0
 2.1 ± 4.6
  
SAA (mg/L)
 3.2 ± 2.8
 6.4 ± 10.5
  
CETP (%CE)
 13.6 ± 5.3
 13.5 ± 4.5
  
PLTP (nmolPC/mL/h)
 6,247 ± 1,851
 6,439 ± 1,617
  
LCAT (%CE)
 3.71 (2.48-5.02)
 2.68 (1.63-3.61)
 0.011
LPL (nmFFA/mL/h)
 2,403 ± 1,304
 4,597 ± 2,616
 <0.001
HL (nmFFA/mL/h)
 4,517 ± 1,622
 3,159 ± 1,424
 <0.001
Pre-beta1-HDL (ng/mL) 11.8 ± 5.7 (n = 33) 22.4 ± 22.5 (n = 34) 0.008

ALT, Alanine aminotransferase. Apo, Apolipoprotein. AST, Aspartate aminotransferase. BMI, Body mass index. CETP, Cholesteryl ester transfer protein. HL. Hepatic lipase. HOMA, Homeostasis model assessment. LCAT, Lecithin: cholesterol acyltransferase. LPL, Lipoprotein lipase. hsCPR, C- reactive protein. SAA, Serum amyloid A. PLTP, Phospholipid transfer protein. Student t test, low HDL-C vs. high HDL-C. Data are presented as mean ± SD. P < 0.05. Pre-beta1-HDL (n = 33 low HDL-C; n = 34 high HDL-C). PLTP, HL and LPL (n = 34 low HDL-C; n = 66 high HDL-C).