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. 2013 Nov 25;11:117. doi: 10.1186/1741-7007-11-117

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Copyright © 2013 Turcatel et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Tracheal epithelial differentiation and apoptosis was not altered by lack of Sox9 gene. (A, B) Phospho-histone-3 (pH3) staining on longitudinal sections of (A) wild-type and (B) mutant tracheas at embryonic day (E) 15.5 did not reveal any change in epithelial cell proliferation. (C) Number of pH3-positive cells per section was similar between wild-type and mutant mouse trachea. (D) Real-time PCR for the apoptotic markers p53, Bcl2, and Gadd45a on total RNA extracted from E15.5 wild-type and mutant tracheas indicated no change in apoptosis. (E) Tracheal epithelial cells were counted on transverse sections of Sox9^fl/fl and Sox9^Δ/Δ E18.5 tracheas, revealing no change in cell number between the two groups. Values are mean ± SD.