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Diversity of histone amino-terminal PTMs. The amino acid sequences at the amino termini of the four core histones are given in the single letter code and possible PTMs are indicated by symbols above and below the sequence. The PTMs are identified at the bottom of the diagram. Lysine residues can be mono-, di- or tri-methylated, or mono- or di-acetylated. Arginine residues can be mono-, or di-methylated and the dimethyl arginine can exist in the ‘syn’ or ‘trans’ conformation.
