Table 1.

Most significant hits in the genome-wide association study

Allele						EA GWAS				NA descent GWAS				Meta-analysisa
SNP	CHR	BP	Gene	Location	1/2b	Allele 1 freq.	Effect size	SE	P	Allele 1 freq.	Effect size	SE	P	Q	Effect size	P
rs1076150c	9	136498761	DBH	Upstream	T/C	0.512	−0.947	0.072	2.74E−32	0.710	−0.779	0.163	7.67E−06	0.35	−0.920	1.38E−44
rs1989787	9	136499412	DBH	Upstream	T/C	0.312	0.924	0.079	2.13E−26	0.196	0.747	0.191	1.92E−04	0.39	0.898	1.50E−34
rs1611115c	9	136500515	DBH	Upstream	T/C	0.248	−1.265	0.070	7.20E−51	0.317	−1.195	0.125	4.10E−15	0.63	−1.248	4.60E−92
rs7540659	1	100196119	FRRS1	Intron	T/A	0.341	−0.024	0.095	0.801	0.462	−0.793	0.160	3.64E−06	0.00	−0.398	0.301
rs60674788	2	35027196	CR617033	Downstream	C/G	0.257	−0.403	0.101	8.11E−05	0.354	−0.536	0.179	0.004	0.52	−0.435	7.64E−07
rs4459781	2	134204665	NCKAP5	Intron	C/T	0.281	−0.499	0.094	2.15E−07	0.215	−0.098	0.209	0.641	0.08	−0.431	5.12E−07
rs77518496	2	143629286	KYNU	Upstream	G/A	0.032	−0.012	0.232	0.959	0.115	1.252	0.253	3.88E−06	0.00	0.616	0.330
rs2351772	2	204079313	NBEAL1	Intron	C/T	0.418	0.346	0.091	1.71E−04	0.527	0.441	0.149	0.004	0.58	0.372	1.61E−06
rs112239800	2	232517876	BC069004	Downstream	G/A	0.102	0.509	0.149	7.38E−04	0.115	1.079	0.268	1.33E−04	0.06	0.645	7.67E−07
rs13095328	3	15226050	DIVA	Intron	C/T	0.100	−0.669	0.143	3.97E−06	0.059	0.634	0.354	0.077	0.00	−0.058	0.929
rs3774729c	3	63982082	ATXN7	Exon	A/G	0.323	0.000	0.086	0.996	0.290	0.869	0.164	9.60E−07	0.00	0.424	0.329
rs56030924	3	63995563	AK023371	Intron	A/G	0.286	0.017	0.090	0.848	0.269	0.885	0.164	6.39E−07	0.00	0.440	0.310
rs831692	3	64003983	PSMD6	Intron	A/G	0.310	0.031	0.089	0.731	0.288	0.893	0.166	6.65E−07	0.00	0.451	0.296
rs56237630	3	64049375	PRICKLE2	Downstream	A/C	0.145	−0.002	0.119	0.988	0.214	0.941	0.182	1.52E−06	0.00	0.460	0.329
rs12639432c	3	134770520	EPHB1	Intron	T/C	0.302	0.339	0.091	2.44E−04	0.462	0.546	0.150	4.71E−04	0.24	0.395	4.16E−07
rs7779937	7	10971712	NDUFA4	Downstream	A/G	0.048	−0.922	0.198	4.74E−06	0.016	0.643	0.660	0.333	0.02	−0.266	0.731
rs13242648	7	35777951	CR595224	Downstream	T/A	0.196	0.554	0.107	3.92E−07	0.136	−0.456	0.231	0.051	0.00	0.070	0.890
rs12701456	7	35827802	SEPT7	Upstream	C/T	0.196	0.547	0.107	5.03E−07	0.132	−0.389	0.231	0.096	0.00	0.101	0.828
rs13255006	8	1989315	MYOM2	Upstream	C/G	0.319	0.500	0.093	1.52E−07	0.172	−0.034	0.216	0.876	0.02	0.268	0.310
rs1338730	9	103520981	MURC	Downstream	C/T	0.402	−0.419	0.085	1.15E−06	0.253	−0.404	0.193	0.039	0.94	−0.417	7.40E−08
rs823919	9	104662606	GRIN3A	Upstream	A/G	0.124	0.582	0.127	6.56E−06	0.172	0.283	0.215	0.191	0.23	0.505	3.98E−06
rs7857468	9	136585380	SARDH	Intron	A/C	0.195	0.544	0.099	8.09E−08	0.170	0.142	0.236	0.549	0.12	0.484	1.19E−07
rs10795764	10	10238394	BC032914	Downstream	C/T	0.434	0.093	0.083	0.265	0.559	0.750	0.133	2.33E−07	0.00	0.413	0.208
rs870553	10	133970542	JAKMIP3	Intron	G/A	0.010	−1.210	0.417	0.004	0.059	−1.262	0.332	2.75E−04	0.92	−1.242	1.77E−06
rs112825992	10	134008571	DPYSL4	Intron	T/C	0.009	−1.252	0.450	0.006	0.055	−1.209	0.320	2.92E−04	0.94	−1.223	2.65E−06
rs4255618	12	131837477	LOC338797	Intron	C/A	0.353	0.388	0.088	1.26E−05	0.322	0.502	0.154	0.002	0.52	0.416	4.62E−08
rs8013529c	14	23649792	SLC7A8	Intron	G/A	0.139	−0.566	0.118	2.37E−06	0.059	0.320	0.328	0.332	0.01	−0.176	0.689
rs12595689	15	86009293	AKAP13	Intron	C/G	0.085	0.010	0.158	0.952	0.102	−1.198	0.222	5.88E−07	0.00	−0.584	0.333
rs117711052	17	74305308	QRICH2	Upstream	C/G	0.024	1.155	0.278	4.12E−05	0.016	1.567	0.627	0.014	0.55	1.223	1.48E−06
rs115172145	17	74310984	PRPSAP1	Intron	C/T	0.024	1.144	0.278	4.77E−05	0.016	1.567	0.627	0.014	0.54	1.213	1.74E−06
rs7228140	18	45907244	ZBTB7C	Intron	C/T	0.046	−0.941	0.194	1.88E−06	0.071	0.439	0.313	0.165	0.00	−0.273	0.692
Conditional analysisd
rs7857468	9	136585380	SARDH	Intron	A/C	0.195	0.500	0.065	2.38E−13	0.170	0.489	0.155	0.002	0.946	0.498	1.15E−16
rs7040170c	9	136586367	SARDH	Intron	G/A	0.221	0.439	0.062	7.82E−12	0.177	0.456	0.153	0.004	0.918	0.442	1.31E−14

^aRandom-effects models were used for SNPs with significant heterogeneity Q values (bold), otherwise fixed-effects models.

^bAllele 1 is the coding allele.

^cDirectly genotyped SNP.

^dRegression analyses including DBH SNPs rs1076150, rs1989787 and rs1611115 as covariates.

P-values in bold meet suggestive (P < 5.0E−06) or genome-wide significance (P < 5.0E−08).