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. 2014 Jul 2;23(23):6223–6234. doi: 10.1093/hmg/ddu342

Figure 2.

Figure 2.

Post-natal endothelial loss of CCM1 phenocopies human disease. (A–F) Live animal magnetic resonance imaging (MRI) images of mice. Each row is from one mouse, kept alive, and imaged successively over time at the ages indicated in the panel. Light blue arrows indicate CCM lesions. (G) Kaplan–Meier survival curve, animals were given tamoxifen at birth and followed through life. Animals that survived were euthanized at 8 months of age. (H) Quantification of CCM brain lesion content over time. Lesion burden is determined as the total number of lesions observed in each tomographic view (slice) of the MRI per mouse. (I–N) Histological staining comparing samples from human CCM1 lesions and lesions from CCM1 knockout mice. H&E staining indicates tissue morphology of the lesion. Iron staining indicates leak into the brain tissue surrounding the lesion. Trichrome staining indicates fibrosis surrounding the lesion. Scale bar at 200 μm. (O) Whole-brain H&E histology of an 8-month old CCM1 knockout mouse. Black arrows indicate CCM lesions.