Table 3.
Meta-analysis results for PC2
| SNP | Allele 1 | Allele 2 | Z-score | P-value | Direction | Chr | Position | Gene | Feature | Left gene | Right gene |
|---|---|---|---|---|---|---|---|---|---|---|---|
| rs681524 | t | c | −5.505 | 3.69E-08 | ?------- | 11 | 116253524 | SIK3 | intron | APOA1 | LOC100129905 |
| rs1393902 | a | g | 5.119 | 3.07E-07 | ++++++++ | 8 | 68584119 | CPA6 | intron | ARFGEF1 | LOC100132812 |
| rs1503369 | t | c | 5.116 | 3.12E-07 | ++++++++ | 8 | 68584552 | CPA6 | intron | ARFGEF1 | LOC100132812 |
| rs1827524 | a | g | 5.104 | 3.32E-07 | ++++++-+ | 8 | 68587796 | CPA6 | intron | ARFGEF1 | LOC100132812 |
| rs1393901 | t | c | 5.100 | 3.40E-07 | ++++++-+ | 8 | 68587888 | CPA6 | intron | ARFGEF1 | LOC100132812 |
| rs6472312 | t | g | −4.994 | 5.92E-07 | ------+- | 8 | 68572052 | CPA6 | intron | ARFGEF1 | LOC100132812 |
| rs1503363 | a | g | −4.940 | 7.80E-07 | ------+- | 8 | 68569258 | CPA6 | intron | ARFGEF1 | LOC100132812 |
Seven SNPs were suggestive genome-wide significant (P < 5 × 10−7) associated with PC2. Top associated SNPs for PC2 are further characterized by corresponding non-effect allele (allele 1) and effect allele (allele 2), the resulting Z-score and significance of association (P-value). The direction of effect (minus or plus) is indicated for each of the eight included populations. If an SNP did not pass QC criteria for a certain SNP, this is indicated by a question mark (?) in the direction column. Mapping information for each SNP is specified by chromosome (chr), base-pair position (position), genes at this locus (gene) and surrounding the locus (left and right gene) as well as feature of the SNP position within a gene (feature).