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. 2014 Oct 13;10:2367–2376. doi: 10.3762/bjoc.10.247

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Copyright © 2014, Morelli et al.

This is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)

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A) IgG levels detected at OD = 1 in individual post 3 sera of BALB/c mice immunization at 0.3 μg saccharide dose of antigen. A) Sera from conjugates 14, 15 and 16 were tested against the monomer-, dimer- and trimer-HSA conjugate, respectively, presenting different linker and protein (see Supporting Information File 1). B) Comparison of anti trimer-HSA antibody levels in sera from conjugates 14–17. Each point represents individual mouse sera; horizontal bars indicate geometric mean titers (GMT) of each group with 95% statistical confidence intervals indicated by upper and lower bars.