Table 1.
Analysis of the different endocytotic inhibitors regarding specificity and efficiency.
| J774A.1 cells | ||||||
| Inhibitors | c (µM) | Exposure (t) | Transferrin | Ctx-b | 1 µm PS | Cell morph.a |
| Chlorpromazine (clathrin) | 100 | 30 min | No inhibition | No inhibition | No inhibition | – |
| MDC (clathrin) | 250 | 1 h 30 min | Inhibition | No inhibition | No inhibition | + |
| MβCD (clathrin, caveolin) | 10·103 | 30 min | No inhibition | No inhibition | No inhibition | + |
| CytoD (phag., macrop) | 4 | 1 h 30 min | No inhibition | No inhibition | Inhibition | + |
| A549 cells | ||||||
| Inhibitors | c (µM) | Exposure (t) | Transferrin | Ctx-b | 1 µm PS | Cell morph.a |
| Chlorpromazine (clathrin) | 100 | 30 min | Inhibition | No inhibition | No inhibition | + |
| MDC (clathrin) | 250 | 1 h 30 min | No inhibition | No inhibition | No inhibition | – |
| MβCD (clathrin, caveolin) | 10·103 | 30 min | Inhibition | Inhibition | No inhibition | + |
| CytoD (phag., macrop.) | 4 | 1 h 30 min | No inhibition | No inhibition | No inhibition | – |
aCell morphology: no cellular impairment (+) and cellular damage (-).