Table 3.
Individual TagSNP association analysis with BMI adjusted by age and gender under an additive genetic model in Pizarra, Hortega and the pooled analysis
| |
|
|
|
|
|
|
BMI |
|||
|---|---|---|---|---|---|---|---|---|---|---|
| Gene | SNP | A1 | MAF | Population | Prior statistical power | N* | Beta | Standard error | STAT** | P |
|
FTO |
rs9939609* |
A |
0.398 |
PIZARRA |
32.77 |
848 |
0.875 |
0.23 |
3.79 |
0.0001573 |
| |
|
|
0.435 |
HORTEGA |
66.65 |
1345 |
0.1348 |
0.15 |
0.90 |
0.368 |
| |
|
|
0.420 |
POOLED |
77.88 |
2215 |
0.2976 |
0.13 |
2.19 |
0.0287 |
| |
rs8044769 |
T |
0.463 |
PIZARRA |
30.96 |
848 |
−0.582 |
0.23 |
−2.54 |
0.0112 |
| |
|
|
0.455 |
HORTEGA |
62.61 |
1331 |
−0.1019 |
0.15 |
−0.68 |
0.495 |
| |
|
|
0.458 |
POOLED |
73.98 |
2198 |
−0.257 |
0.13 |
−1.90 |
0.0571 |
| |
rs7190492 |
A |
0.328 |
PIZARRA |
5.06 |
845 |
−0.559 |
0.23 |
−2.34 |
0.0192 |
| |
|
|
0.337 |
HORTEGA |
5.16 |
1346 |
0.2065 |
0.16 |
1.29 |
0.195 |
| |
|
|
0.333 |
POOLED |
5.21 |
2213 |
−0.07336 |
0.14 |
−0.51 |
0.6076 |
| |
rs6499640 |
G |
0.376 |
PIZARRA |
5.01 |
847 |
0.336 |
0.23 |
1.43 |
0.1511 |
| |
|
|
0.381 |
HORTEGA |
5.02 |
1347 |
0.09312 |
0.15 |
0.60 |
0.543 |
| |
|
|
0.379 |
POOLED |
5.02 |
2216 |
0.2335 |
0.13 |
1.69 |
0.0911 |
|
MC4R |
rs17782313* |
C |
0.199 |
PIZARRA |
9.69 |
848 |
0.575 |
0.28 |
1.98 |
0.0478 |
| |
|
|
0.191 |
HORTEGA |
16.33 |
1348 |
0.1167 |
0.19 |
0.60 |
0.544 |
| |
|
|
0.195 |
POOLED |
20.23 |
2218 |
0.3111 |
0.17 |
1.80 |
0.0716 |
|
MTCH2 |
rs10838738 |
G |
0.352 |
PIZARRA |
5.80 |
845 |
0.453 |
0.24 |
1.88 |
0.0603 |
| |
|
|
0.353 |
HORTEGA |
6.98 |
1348 |
0.0972 |
0.15 |
0.62 |
0.536 |
| |
|
|
0.353 |
POOLED |
7.61 |
2215 |
0.1698 |
0.14 |
1.19 |
0.2318 |
|
NEGR1 |
rs3101336 |
A |
0.375 |
PIZARRA |
7.89 |
848 |
−0.084 |
0.24 |
−0.34 |
0.7277 |
| |
|
|
0.343 |
HORTEGA |
11.89 |
1348 |
−0.403 |
0.15 |
−2.64 |
0.0083 |
| |
|
|
0.355 |
POOLED |
14.23 |
2210 |
−0.1586 |
0.14 |
−1.13 |
0.2561 |
|
ATXN2L |
rs8049439 |
C |
0.375 |
PIZARRA |
8.87 |
848 |
−0.139 |
0.23 |
−0.58 |
0.5576 |
| |
|
|
0.338 |
HORTEGA |
14.15 |
1344 |
0.3292 |
0.15 |
2.13 |
0.0331 |
| |
|
|
0.353 |
POOLED |
17.35 |
2209 |
0.1715 |
0.14 |
1.22 |
0.2198 |
|
HTR2C |
rs3813929 |
T |
0.157 |
PIZARRA |
10.16 |
847 |
−0.406 |
0.35 |
−1.16 |
0.2455 |
| |
|
|
0.182 |
HORTEGA |
19.46 |
1342 |
−0.4365 |
0.23 |
−1.89 |
0.0577 |
| |
|
|
0.172 |
POOLED |
23.29 |
2211 |
−0.5551 |
0.20 |
−2.68 |
0.0073 |
|
ADRB2 |
rs12654778 |
A |
0.388 |
PIZARRA |
3 5.35 |
848 |
0.271 |
0.23 |
1.16 |
0.2452 |
| |
|
|
0.380 |
HORTEGA |
69.22 |
1347 |
−0.1452 |
0.15 |
−0.95 |
0.339 |
| |
|
|
0.382 |
POOLED |
80.65 |
2217 |
0.01463 |
0.13 |
0.10 |
0.9152 |
|
SEC16B |
rs10913469 |
C |
0.142 |
PIZARRA |
9.33 |
848 |
0.392 |
0.32 |
1.21 |
0.2266 |
| |
|
|
0.152 |
HORTEGA |
16.43 |
1347 |
−0.1609 |
0.20 |
−0.78 |
0.432 |
| |
|
|
0.148 |
POOLED |
19.78 |
2216 |
0.00939 |
0.18 |
0.05 |
0.96 |
|
TMEM18 |
rs4854344 |
G |
0.172 |
PIZARRA |
15.26 |
847 |
−0.198 |
0.30 |
−0.64 |
0.5173 |
| |
|
|
0.169 |
HORTEGA |
30.08 |
1348 |
−0.3012 |
0.20 |
−1.48 |
0.138 |
| |
|
|
0.170 |
POOLED |
37.86 |
2217 |
−0.243 |
0.18 |
−1.33 |
0.1815 |
|
INSIG2 |
rs7566605 |
C |
0.327 |
PIZARRA |
13.68 |
846 |
0.101 |
0.24 |
0.41 |
0.676 |
| |
|
|
0.321 |
HORTEGA |
26.42 |
1348 |
−0.0301 |
0.16 |
−0.18 |
0.8514 |
| |
|
|
0.322 |
POOLED |
33.12 |
2216 |
0.1152 |
0.14 |
0.79 |
0.4265 |
|
ADIPOQ |
rs17300539 |
A |
0.126 |
PIZARRA |
7.59 |
844 |
−0.072 |
0.33 |
−0.21 |
0.8298 |
| |
|
|
0.118 |
HORTEGA |
11.08 |
1348 |
0.1146 |
0.22 |
0.51 |
0.6082 |
| |
|
|
0.120 |
POOLED |
13.15 |
2214 |
0.0818 |
0.20 |
0.40 |
0.6838 |
| |
rs3774261 |
A |
0.495 |
PIZARRA |
10.96 |
844 |
−0.036 |
0.22 |
−0.16 |
0.8727 |
| |
|
|
0.461 |
HORTEGA |
19.84 |
1346 |
−0.0549 |
0.15 |
−0.36 |
0.7138 |
| |
|
|
0.473 |
POOLED |
26.42 |
2210 |
0.0609 |
0.13 |
0.45 |
0.6503 |
|
ETV5 |
rs7647305 |
T |
0.205 |
PIZARRA |
10.76 |
838 |
0.022 |
0.28 |
0.079 |
0.9364 |
| |
|
|
0.215 |
HORTEGA |
19.82 |
1325 |
0.2402 |
0.18 |
1.30 |
0.1927 |
| |
|
|
0.213 |
POOLED |
24.39 |
2175 |
0.2106 |
0.16 |
1.26 |
0.2077 |
|
GNPDA2 |
rs10938397 |
G |
0.440 |
PIZARRA |
11.60 |
848 |
−0.338 |
0.22 |
−1.52 |
0.1278 |
| |
|
|
0.455 |
HORTEGA |
21.56 |
1348 |
−0.048 |
0.15 |
−0.32 |
0.7492 |
| |
|
|
0.449 |
POOLED |
26.80 |
2218 |
−0.1687 |
0.13 |
−1.26 |
0.2078 |
|
PRL |
rs4712652 |
A |
0.453 |
PIZARRA |
5.28 |
828 |
0.203 |
0.23 |
0.87 |
0.3846 |
| |
|
G |
0.487 |
HORTEGA |
5.69 |
1326 |
0.0367 |
0.15 |
0.24 |
0.8056 |
| |
|
A |
0.489 |
POOLED |
5.91 |
2175 |
−0.115 |
0.13 |
−0.84 |
0.3976 |
|
PTER |
rs10508503 |
T |
0.093 |
PIZARRA |
5.10 |
841 |
−0.119 |
0.39 |
−0.30 |
0.7617 |
| |
|
|
0.112 |
HORTEGA |
5.27 |
1315 |
−0.279 |
0.23 |
−1.21 |
0.2238 |
| |
|
|
0.105 |
POOLED |
5.34 |
2174 |
−0.3695 |
0.21 |
−1.71 |
0.0866 |
|
BDNF |
rs925946 |
T |
0.282 |
PIZARRA |
10.40 |
848 |
0.128 |
0.24 |
0.51 |
0.6046 |
| |
|
|
0.266 |
HORTEGA |
17.97 |
1348 |
−0.071 |
0.16 |
−0.44 |
0.6578 |
| |
|
|
0.272 |
POOLED |
22.37 |
2215 |
0.0795 |
0.14 |
0.54 |
0.5855 |
| |
rs10501087 |
C |
0.253 |
PIZARRA |
10.01 |
845 |
0.033 |
0.26 |
0.12 |
0.8988 |
| |
|
|
0.231 |
HORTEGA |
16.77 |
1348 |
0.0875 |
0.17 |
0.49 |
0.6231 |
| |
|
|
0.240 |
POOLED |
20.96 |
2214 |
0.1472 |
0.15 |
0.93 |
0.3493 |
|
FAIM2 |
rs7138803 |
A |
0.352 |
PIZARRA |
7.38 |
844 |
0.155 |
0.24 |
0.65 |
0.5159 |
| |
|
|
0.352 |
HORTEGA |
10.92 |
1348 |
−0.0643 |
0.15 |
−0.42 |
0.675 |
| |
|
|
0.351 |
POOLED |
12.81 |
2214 |
0.0513 |
0.14 |
0.36 |
0.7129 |
|
MAF |
rs1424233 |
A |
0.483 |
PIZARRA |
5.29 |
846 |
−0.192 |
0.23 |
−0.83 |
0.4074 |
| |
|
G |
0.499 |
HORTEGA |
5.70 |
1348 |
0.2336 |
0.14 |
1.57 |
0.1158 |
| |
|
A |
0.495 |
POOLED |
5.92 |
2216 |
−0.2422 |
0.13 |
−1.79 |
0.0725 |
|
NPC1 |
rs1805081 |
G |
0.329 |
PIZARRA |
5.25 |
845 |
−0.014 |
0.24 |
−0.05 |
0.9553 |
| |
|
|
0.352 |
HORTEGA |
5.64 |
1345 |
0.0046 |
0.15 |
0.03 |
0.9758 |
| |
|
|
0.344 |
POOLED |
5.83 |
2212 |
−0.0463 |
0.14 |
−0.32 |
0.7432 |
|
KCTD15 |
rs11084753 |
A |
0.395 |
PIZARRA |
5.62 |
846 |
0.093 |
0.23 |
0.39 |
0.6897 |
| |
|
|
0.352 |
HORTEGA |
6.44 |
1343 |
−0.1562 |
0.15 |
−1.01 |
0.31 |
| |
|
|
0.367 |
POOLED |
6.94 |
2210 |
0.0573 |
0.13 |
0.41 |
0.6781 |
|
CTNNBL1 |
rs6013029 |
T |
0.091 |
PIZARRA |
5.79 |
847 |
0.014 |
0.39 |
0.036 |
0.9708 |
| |
|
|
0.066 |
HORTEGA |
6.44 |
1348 |
−0.1522 |
0.30 |
−0.50 |
0.6133 |
| 0.076 | POOLED | 7.16 | 2216 | 0.1139 | 0.25 | 0.44 | 0.6547 | |||
A1: minor allele, *Number of non-missing individuals included in the analysis (top) and frequency of the haplotype in the sample (bottom); **t statistic coefficient; p-values are not corrected for multiple testing; Bold type indicates significant association after Bonferroni correction. **The SNPs, rs4788102 in the SH2B1 and rs4074134 of the BDNFOS genes are not included because are in high LD with the SNPs, rs8049439 of the ATXN2L gene (r2 0.94) and rs10501087of the BDNF gene (r2 0.95), respectively.