Table 6.
HYPs meeting significance criteria in matched real and randomized data sets
| Richness and concordance p-value threshold |
TNF |
PI3K inhibitor |
High fat diet |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Random | Real | Ratio | Random | Real | Ratio | Random | Real | Ratio | |
| 0.2 |
13 |
94 |
14% |
20 |
81 |
25% |
7 |
33 |
21% |
| 0.15 |
9 |
84 |
11% |
12 |
66 |
18% |
4 |
25 |
16% |
|
0.1 |
3 |
58 |
5% |
4 |
45 |
9% |
1 |
13 |
8% |
| 0.05 |
1 |
41 |
2% |
1 |
29 |
3% |
0 |
5 |
0% |
| 0.01 |
0 |
24 |
0% |
0 |
14 |
0% |
0 |
0 |
N/A |
| 0.005 | 0 | 21 | 0% | 0 | 6 | 0% | 0 | 0 | N/A |
For each example data set (TNF, PI3K inhibitor, and high fat diet), 1000 matched random data sets were generated. The number of HYPs meeting significance criteria at each p-value threshold is indicated, for random data the median number of significant mechanisms is shown.
BOLD indicates the 0.1 p-value threshold applied to analysis of the three example data sets.