Table 2.
Effect of I424M substitution on Env sensitivity to PG9, PG16, VRC01 and pooled plasma. Values represent inhibitory concentration (IC50) of MAbs tested. For plasma specimens, values represent reciprocal dilution at which 50% neutralization was observed.
| Envelope | PG9 | PG16 | VRC01 | b12 | Pooled plasma |
|---|---|---|---|---|---|
| 4-2.J45 (I424) | 0.018 | 0.16 | 0.42 | >10 | 67 |
| 4-2.J45 (M424) | 0.125 | 6 | 0.6 | >10 | 7046 |
| 11-3.J3 (I424) | 0.44 | 0.47 | 0.8 | >10 | 443 |
| 11-3.J3 (M424) | 0.49 | 0.92 | 0.51 | >10 | 2938 |
| JRFL (I424) | >10 | >10 | 0.1 | 0.1 | 97 |
| JRFL (M424) | >10 | >10 | 0.05 | 0.05 | 132 |
| YU2 (I424) | >10 | 0.15 | 0.06 | 3.55 | 134 |
| YU2 (M424) | 1.26 | 0.05 | 0.05 | 0.11 | 324 |
| RHPA4259.7 (I424) | >10 | 0.12 | <0.03 | 0.23 | 108 |
| RHPA4259.7 (M424) | >10 | 0.21 | <0.03 | 0.06 | 280 |