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. 2014 Sep 15;53(43):6766–6775. doi: 10.1021/bi500680s

Table 2. Thermodynamic Analysis of the Association of Skelemin and Integrin by ITC.

titrant C-terminal β3 N-terminal β3 αIIb
protein Sk4 Sk45 Sk45
Kd (μM) 10.7 ± 9.9 37.2 ± 180a 14.2 ± 4.3
ΔG (kJ/mol) –28.3 –25.3 –27.7
ΔH (kJ/mol) –0.7 ± 0.1 –1.7 ± 0.9a –1.6 ± 0.1
–TΔS (kJ/mol) –27.6 –23.6 –26.1
stoichiometry, n 0.99 ± 0.10 1.30 ± 0.41a 1.26 ± 0.05
a

Titration of Sk45 with N-terminal β3 was noisy, resulting in inaccurate fitting.