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. 2014 Sep 9;32(11):2188–2198. doi: 10.1097/HJH.0000000000000309

FIGURE 2.

FIGURE 2

EUGR male rats developed increased pulmonary artery pressure at 9 weeks of age. Pulmonary artery pressure (PAP; a) and right ventricle-to-left ventricle and septum (RV to LV + S) weight ratio (b) in EUGR and control rats are shown at 9 weeks of age. Representative lung histological sections of controls (c) and EUGR (d) are shown, demonstrating hypertrophy of the arterial medial wall induced by EUGR. Note significant medial thickness (d), and the prominent obstructive intimal thickening at the level of small arteries and arterioles was observed in EUGR group (200×). The bar graph represents the %vascular medial wall diameter (e) and percentage vascular medial wall area (f) of the small pulmonary arteries. (g) eNOS protein expression in PVEC. Western blots for eNOS utilize beta-actin as an internal control. Note that eNOS protein level in EUGR was significantly lower than that in the control (n = 5–6; ∗P < 0.05). eNOS, endothelial nitric oxide synthase; EUGR, extrauterine growth restriction; PVECs, pulmonary vascular endothelial cells.