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. 2014 Oct 9;30(43):12941–12949. doi: 10.1021/la502144z

Figure 3.

Figure 3

Cyto- and genotoxicity of studied substances. (a) Viability of A549 human lung cancer cells. Cells were incubated within 24 h with following formulations: 1, Empty Janus nanoparticles, 2, Free nonbound DOX, 3, Janus nanoparticles with CUR, 4, Janus nanoparticles with DOX, 5, Janus nanoparticles with CUR and DOX. (b, c) Genotoxicity (formation of micronuclei) of Janus nanoparticles and corresponding controls. (b) Quantitative analysis of micronuclei formation. (c) Representative fluorescence microscopy images of cell incubated within 24 h with 6, Media (negative control), 7, EMS (positive control, and 8, Janus nanoparticles. Means ± SD are shown. *P < 0.05 when compared with empty nanoparticles; +P < 0.05 when compared with free DOX; †P < 0.05 when compared with nanoparticles with CUR; and ‡P < 0.05 when compared with nanoparticles with DOX.