Table 1.
Time courses of coagulation and inflammation profile associated with microangiopathic hemolytic parameters
| Day 1 | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | Day 7 | |
|---|---|---|---|---|---|---|---|
| Platelet count (×104/μL) |
23.0 |
4.5 |
2.2 |
2.3 |
2.4 |
1.0 |
3.2 |
| LDH (mg/dL) |
217 |
1160 |
2267 |
1836 |
1412 |
1482 |
|
| Serum Cr (mg/dL) |
0.51 |
2.09 |
3.35 |
|
|
3.82 |
4.07 |
| APTT (seconds) |
|
51 |
|
|
39 |
32 |
28 |
| PT-INR |
|
1.63 |
1.36 |
1.52 |
1.03 |
0.90 |
0.95 |
| FDP (μg/mL) |
|
645 |
259 |
60 |
30 |
|
|
| D-dimer (μg/mL) |
|
|
103.4 |
|
|
|
|
| Fibrinogen (mg/dL) |
|
206 |
425 |
537 |
526 |
566 |
588 |
| Anti-thrombin III (%) |
|
90 |
60 |
74 |
49 |
|
62 |
| Protein-C (%) |
|
<1.0 |
|
23 |
<1.0 |
|
32 |
| PAI-1 (ng/mL) |
|
146.8 |
148.0 |
172.6 |
24.7 |
|
38.7 |
| Procalcitonin (ng/mL) |
|
141.9 |
195.1 |
125.6 |
94.9 |
|
33.6 |
| CRP (mg/dL) | 0.66 | 6.91 | 15.79 | 19.77 | 13.53 | 11.73 |
The coagulation profiles of APTT and PT were normalized on day 6 as a result of the treatment with antibiotics and continuous hemodiafiltration (CHDF). Antithrombin III (1500 unit) was administered on day 3.