Table 6. Genome sequences of Bosnia A strain identical to TPE strains and different from TPA strains^a.

	Non-coding sequences (altogether 207 bp)		Coding sequences (altogether 2128 bp)
Nucleotide difference	Number of differences	Number of affected nucleotides	Number of differences	Number of affected nucleotides	Affected gene	Predicted proteinb	Function
deletion	8	1× single bp	13	3× single bp	TENDBA_0103c	RecQ	DNA replication, repair and recombination
		1×2 bp		(altogether 3 bp of protein elongation)	TENDBA_0314c	TCHP	Unknown
		1×6 bp			TENDBA_0911ac	HP	Unknown
		1×9 bp		1×9 bp	TENDBA_0067	CHP	Unknown
		1×13 bp		1×27 bp	TENDBA_0461a	HP	Unknown
		1×17 bp		8×3 bp	TENDBA_0027	HlyC	Cell processes
		1×30 bp		(altogether 60 bp of protein shortening)	TENDBA_0136d	TCHP	Virulence
		1×33 bp			TENDBA_0304	TCHP	Unknown
		(altogether 111 bp)			TENDBA_0314	TCHP	Unknown
					TENDBA_0619	TCHP	Unknown
					TENDBA_0621 (2x)	TprJ	Virulence
					TENDBA_0856a/TENDBA_0858	HP/TCHP	Unknown/Unknown
insertion	3	3× single bp	9	1×2 bp	TENDBA_0009c	TprA	Virulence
		(altogether 3 bp)		1×52 bp	TENDBA_0548ac	HP	Unknown
				1×65 bp	TENDBA_0126bc	HP	Unknown
				1×635 bp	TENDBA_0316c	TprGI	Virulence
				(altogether 754 bp of protein truncation or elongation due to frameshift mutations)
				5×3 bp	TENDBA_0129a/TENDBA_0129b	HP/HP	Unknown/Unknown
				(altogether 15 bp of protein elongation)	TENDBA_0462 (2x)	CHP	Unknown
					TENDBA_0856a/TENDBA_0858	HP/TCHP	Unknown/Unknown
					TENDBA_0967	TCHP	Unknown
substitution	93		1296	631 different aa	TENDBA_0117	TprC	Virulence
				427 identical aa	TENDBA_0131	TprD	Virulence
					TENDBA_0133	TCHP	Unknown
					TENDBA_0134	TCHP	Unknown
					TENDBA_0304	TCHP	Unknown
					TENDBA_0314	TCHP	Unknown
					TENDBA_0462	CHP	Unknown
					TENDBA_0619	TCHP	Unknown
					TENDBA_0620	TprI	Virulence
					TENDBA_0621	TprJ	Virulence

^aThe tprK gene (TENDBA_0897) was excluded from this list of differences because of high intra-strain sequence diversity.

^bHP – hypothetical protein, CHP – conserved hypothetical protein, TCHP – treponemal conserved hypothetical protein.

^csee also Table 2.

^dTPA and TPE orthologs to TENDBA_0136 have been experimentally shown to bind human fibronectin [28].