Table 2.

Prevalence of Seizure, unadjusted and adjusted Prevalence Risk Ratios (PRR) for breakthrough seizures

	Number with seizure n/N	Percentage with seizure (%)	Unadjusted PRR 95% CI	p-value	Adjusted PRR**, 95% CI	p-value
Sex
Female	82/111	73.9	0.96 (0.83,1.11)		0.96 (0.84,1.11)
Male	111/145	76.6	1.0	0.618	1.0	0.581
Age group
18-20	78/97	80.4	1.0		1.0
21-29	59/80	73.8	0.92 (0.78, 1.08)	0.301	0.91 (0.76,1.08)	0.266
30-44	39/56	69.6	0.87 (0.71,1.06)	0.157	0.86 (0.68, 1.08)	0.181
45+	17/23	73.9	0.92 (0.71,1.19)	0.529	0.92 (0.65,1.30)	0.633
Marital status
Never married/single	148/195	75.9	1.0		1.0
Married	35/45	77.8	1.02 (0.86,1.22)	0.784	1.06 (0.85,1.31)	0.602
Divorced/separated/widowed	10/16	62.5	0.82 (0.56, 1.21)	0.327	0.87 (0.56,1.34)	0.531
Level of education
None	13/17	76.5	1.0		1.0
Primary (P1-P7)	77/101	76.2	1.0 (0.75,1.38)	0.983	0.98 (0.73,1.30)	0.864
Secondary (S1-S6)	77/102	75.5	0.99 (0.74,1.31)	0.930	0.97 (0.73,1.30)	0.842
Tertiary	26/36	72.2	0.94 (0.68, 1.32)	0.737	0.98 (0.70,1.37)	0.897
Duration on Treatment
<1 years	30/32	93.8	1.0		1.0
1-5	109/150	72.7	0.78 (0.68,0.89)	<0.000	0.79 (0.68, 0.91)	0.001
5+	54/74	73.0	0.78 (0.66,0.92)	0.004	0.82 (0.68,0.98)	0.025
Number of drugs taken
One drug	64/83	77.1	1.0		1.0
Two drugs	94/124	75.8	0.98 (0.84,1.15)	0.828	0.98 (0.85,1.15)	0.839
Three drugs	35/49	71.4	0.93 (0.75,1.15)	0.481	0.93 (0.76,1.15)	0.525
Doses missed
None	136/187	72.7	1.0		1.0
1-3 doses	23/32	71.9	0.99 (0.78,1.25)	0.921	1.04 (0.82,1.30)	0.764
> 3 doses	34/37	91.9	1.26 (1.11,1.44)	<0.0001	1.33 (1.16,1.52)	<0.000
Hours slept (hours)
<=6	18/26	69.2	1.0		1.0
7-9	109/145	75.2	1.09 (0.83,1.43)	0.555	1.11(0.83,1.49)	0.467
10+	66/85	77.7	1.12 (0.85,1.49)	0.424	1.18 (0.87,1.59)	0.283

**Adjusted for age, sex, marital status, education level, drug type, duration of anti-epileptic therapy, number of drug doses missed and hours slept at night.

N- total number of study participants, n – number of subjects with seizures.