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. 2014 Nov 6;9(11):e110124. doi: 10.1371/journal.pone.0110124

Table 1. Effects of danshensu on plasma TXB2 and 6-keto-PGF levels and TXB2-6-keto-PGF ratio in rats in the arteriovenous shunt model.

Group Dose(mg/kg) TXB2 (pg/mL) 6-keto-PGF (pg/mL) TXB2/6-keto-PGF
Normal 180.0±8.3 487.3±16.6 0.38±0.01
Thromb 552.2±18.9## 602.5±20.4## 0.93±0.03##
Thromb+Aspirin 20 56.5±1.9*** 190.5±7.5*** 0.30±0.01***
Thromb +Danshensu 15 258.1±10.2** 621.7±19.8* 0.40±0.01**
30 228.7±11.5** 638.3±22.1** 0.37±0.02**
60 206.4±8.9** 649.2±15.8** 0.35±0.02**

Blood was drawn from the abdominal aorta at the end of arteriovenous shunt test period and anticoagulated with indomethacin-EDTA-Na2. Plasma samples were prepared by centrifugation and analyzed by radioimmunoassay. Data are expressed as mean±SEM (each group, n = 10). # P<0.05, ## P<0.01 compared with normal group, *P<0.05, **P<0.01, ***P<0.001 compared with thrombotic control group.