Table 1. Effects of danshensu on plasma TXB2 and 6-keto-PGF1α levels and TXB2-6-keto-PGF1α ratio in rats in the arteriovenous shunt model.
Group | Dose(mg/kg) | TXB2 (pg/mL) | 6-keto-PGF1α (pg/mL) | TXB2/6-keto-PGF1α |
Normal | 180.0±8.3 | 487.3±16.6 | 0.38±0.01 | |
Thromb | 552.2±18.9## | 602.5±20.4## | 0.93±0.03## | |
Thromb+Aspirin | 20 | 56.5±1.9*** | 190.5±7.5*** | 0.30±0.01*** |
Thromb +Danshensu | 15 | 258.1±10.2** | 621.7±19.8* | 0.40±0.01** |
30 | 228.7±11.5** | 638.3±22.1** | 0.37±0.02** | |
60 | 206.4±8.9** | 649.2±15.8** | 0.35±0.02** |
Blood was drawn from the abdominal aorta at the end of arteriovenous shunt test period and anticoagulated with indomethacin-EDTA-Na2. Plasma samples were prepared by centrifugation and analyzed by radioimmunoassay. Data are expressed as mean±SEM (each group, n = 10). # P<0.05, ## P<0.01 compared with normal group, *P<0.05, **P<0.01, ***P<0.001 compared with thrombotic control group.