Figure 1. Representative anatomical images from each cohort.

Representative coronal T₁-weighted scout image (A) and axial magnetization transfer (MT) images for each cohort (B). The length (L) of the femur was measured from the coronal scout image, and the axial MT volumes were centered 1/3 this length (L/3), as measured from the lower extremity. The most proximal (blue line, B.a) and distal slices (green line, B.b) are shown along with the region of interest (red overlay) for the sciatic nerve (SN). The tibial and common peroneal branches of the SN were resolvable in the more distal slices. Note the hypertrophy of the SN in the patient with Charcot-Marie-Tooth type 1A (CMT1A) and the muscle atrophy and fat replacement in the patient with Charcot-Marie-Tooth type 2A (CMT2A) (white arrow). HNPP = hereditary neuropathy with liability to pressure palsies.