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. 2014 Nov 6;9(11):e111453. doi: 10.1371/journal.pone.0111453

Figure 9. Caudate Migratory Stream (CMS).

Figure 9

A–D. Proliferating cells in the medial wall of the caudate facing the lateral ventricles and in the dorsal and lateral walls have similar distribution. A. Distribution of proliferating cells in the lateral walls of the lateral ventricles (LatW) formed by the medial wall of the caudate and in the dorsal and lateral walls of the caudate. a. EdU-labeled nuclei in the LatW are shown as yellow dots and in the dorsal and lateral walls of the caudate as blue dots. b, c. Each EdU-labeled nucleus is shown as a colored dot with colors assigned according to the number of neighboring EdU-labeled nuclei located closer than 200 µm to this nucleus. Scale is shown on the right. EdU-labeled nuclei in the LatW and in the dorsal and lateral walls of the caudate are shown as they are located in the mouse brain (b) or virtually separated by 1 mm (c). B. Distribution of proliferating cells in the lateral walls of the lateral ventricles formed by the medial wall of the caudate and in the dorsal and lateral walls of the caudate. Proliferating cells in the medial caudate wall facing the lateral ventricles are shown with yellow arrows and in the dorsal and lateral walls with blue arrows. The point of transition between caudate walls facing the lateral ventricle and other walls is shown with the gray arrows. Sagittal sections. Section positions are shown on diagrams on the top. The red arrow on panel d shows the point of the RMS departure from the CMS. Lateral Ventricles (LV), Caudoputamen (CP), Rostral Migratory Stream (RMS). C. Distribution of proliferating cells in the LatW and in the dorsal and lateral walls of the caudate (Caud) along the anteroposterior axis of the brain. The number of EdU-labeled nuclei in a 50 µm brain section is shown along the vertical axis of the charts. The distance from the anterior end of the brain is shown along the horizontal axis of the charts. D. Density of proliferating cells in the LatW and Caud along the anteroposterior axis of the brain. The average number of neighboring EdU-labeled nuclei located closer than 200 µm to each EdU-labeled nucleus in a 50 µm brain section is shown along the vertical axis of the charts. The distance from the anterior end of the brain is shown along the horizontal axis of the charts. E–G. Distribution of proliferating cells in walls of the lateral ventricles. E, F. Distribution of proliferating cells in the medial wall of the lateral ventricles (MedW) and at the place of the lateral and medial wall fusion in the anterior part of the lateral ventricles (FusW) (E) and in the dorsal wall of the lateral ventricles (DorW) (F). The number of EdU-labeled nuclei in a 50 µm brain section is shown along the vertical axis of the charts. The distance from the anterior end of the brain is shown along the horizontal axis of the charts. G. Distribution of proliferating cells in walls of the lateral ventricles. (a–f. Lateral view; g. Frontal view and h. Dorsal view). The cell location is indicated on the figure. Each EdU-labeled nucleus is shown as a colored dot with colors assigned according to Table 2. Abbreviated names are given according to Table 2. 120 days-old mouse one hour post EdU injection.