Table 1. Demographic data of Discovery and Replication Samples.

	Discovery Sample				Replication Samples								Whole Sample
	USA				Replication Sample 1 (Canada)				Replication Sample 2 (Spain)
	Fam ET	Spo ET	All ET	Cont	Fam ET	Spo ET	All ET	Cont	Fam ET	Spo ET	All ET	Cont	Fam ET	Spo ET	All ET	Cont
	(n = 151)	(n = 106)	(n = 257)	(n = 376)	(n = 113)	(n = 178)	(n = 291)	(n = 328)	(n = 39)	(n = 74)	(n = 113)	(n = 182)	(n = 303)	(n = 358)	(n = 661)	(n = 886)
Age*(SD)	74.28(11.66)	75.77(12.02)	74.90(11.83)	67.12(12.26)	71.76(15.08)	74.91(12.93)	73.65(13.92)	73.26(12.37)	60.00(15.10)	65.96(14.55)	63.88(15.01)	68.92(10.43)	71.54(14.20)	73.30(13.56)	72.48(13.89)	69.63(12.25)
Age*range	35–96	46–98	35–98	29–88	32–99	23–97	23–99	27–99	19–88	22–91	19–91	12–110	19–99	22–98	19–99	12–110
AAO§(SD)	47.04(19.91)	56.10(18.73)	50.66(19.95)	NA	52.10(19.06)	56.33(16.39)	54.74(17.56)	NA	49.77(18.83)	55.85(20.87)	53.86(20.43)	NA	49.21(19.61)	56.16(18.12)	53.00(19.12	NA
AAO§range	5–84	6–88	5–88	NA	15–87	12–87	12–87	NA	14–78	10–89	10–89	NA	5–87	6–89	5–89	NA
Female,%	54.31	51.89	53.31	55.32	58.41	55.62	56.70	69.21	53.85	50.00	51.33	54.95	55.78	53.35	54.46	60.38

Fam ET = familial essential tremor; Spo ET = sporadic essential tremor; Cont = Healthy controls; y = years; AAO = age at onset; SD = standard deviation; NA = data not applicable.

*Age was not available for 57 subjects (6 familial, 17 sporadic cases and 34 controls) from Replication Sample 1 and for 11 subjects (1 familial, 3 sporadic cases and 7 controls) from Replication Sample 2.

^§AAO was not available for 22 subjects (10 familial and 12 sporadic cases) from the Discovery Sample, for 27 subjects (14 familial and 13 sporadic cases) from the Replication Sample 1 and for 6 subjects (4 familial and 2 sporadic cases) from Replication Sample 2.