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. Author manuscript; available in PMC: 2015 Apr 8.
Published in final edited form as: Toxicol Pathol. 2014 Feb 4;42(4):672–683. doi: 10.1177/0192623313518664

Figure 5.

Figure 5

Evaluation of plasma von Willebrand Factor (VWF) as a drug-induced vascular injury (DIVI) biomarker. Dogs were treated with 15, 60, or 240 mg/kg ZD6169, a PCO, with blood collected 0- (predose), 1.5-, 3-, 6-, and 24-hr postdose. Sodium citrate anticoagulated blood was centrifuged to obtain platelet poor plasma with VWF analyzed using the STA Compact1. Plotted is the average fold difference from 0 hr with standard error. Heart rate (HR) and mean arterial blood pressure (MAP) were recorded 1-hr postdose. Dogs were euthanatized 24-hr postdose, and hearts were processed, fixed, sectioned, and hematoxylin and eosin (H&E) stained. N = 2 dogs per group.