Table 1. Dose-response of plasma VWF, VWFpp, VWFpp:VWF ratio, and incidence of vascular lesions in dogs administered dopamine (DA).

Groupa	Dopamine (mg/kg)	VWFb	VWFppb	VWFpp:VWFb	Lesion (%)c
1d	0	96–157	55–91	0.36–0.95	0
2	3.6	127–173	76–136	0.58–1.03	0
3	10.8	103–215	165–250	0.86–2.13	20
4	27	149–228	248–467	1.43–2.43	100

^aFive dogs per group.

^bPlasma samples collected at 1-hr postdose initiation. VWF and VWFpp are reported as percentage of normal pooled dog plasma.

^cNecropsy at 24-hr postdose initiation.

^dOne dog was dropped from group analysis due to extremely low VWF value (25).