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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Contrast Media Mol Imaging. 2014 May 6;10(1):51–58. doi: 10.1002/cmmi.1604

Figure 1.

Figure 1

Structure and proton spectra of lanthanide ions (Ln3+) chelated with DOTA-4AmP8-. (A) Chemical structure of DOTA-4AmP8- chelated with either thulium (Tm3+) or ytterbium (Yb3+). 1H MR spectra of 10 Mm solutions for (B) Tm-DOTA-4AmP5- and (C) Yb-DOTA-4AmP5- at 11.7 T at 35 °C and pH 7.4. W indicates water proton resonance, the different H's indicate the different non-exchangeable proton resonances for biosensor imaging of redundant deviation in shifts (BIRDS) and –NH represents the exchangeable proton resonances for chemical exchange of saturation transfer (CEST). Characterization of BIRDS and CEST for Ln- DOTA-4AmP5- are shown in Figures. 2 and 3 respectively.