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. 2014 Nov 6;9(11):e112082. doi: 10.1371/journal.pone.0112082

Figure 6. Final refined model of the tetrameric complex.

Figure 6

A) Average structure of the last 20 ns of MD simulation of the model after SMD. B) Detail of the UbcH10-Cys-cap loop interactions. C) Detail of UbcH10-Cys region involved in hydrophobic interactions; D) Detail of the UbcH10-Cys region involved in polar interactions; E) Detail of the hydrophobic interactions between hUbA1 UFD and UbcH10. F) Detail of the polar interactions between hUbA1 UFD and UbcH10. Colour code: hUbA1, grey; Ub(T) yellow; Ub(A), orange; UbcH10, violet. Catalytic cysteins were highlighted in spheres. Apolar hydrogens were omitted for the sake of clarity. The van der Waals interactions are highlighted with transparent Connolly surfaces.