Figure 2. Bacterial load in the brain or CSF as a function of blood bacteremia in rabbits following intranasal instillation of Vollum spores.

Rabbits were infected IN with 10⁷ CFU of Vollum spores (500 LD₅₀). 32 h post infection blood, CSF and brain total bacterial load were determined. The brain (total CFU) and CSF (CFU/ml) of individual animal is plotted in correlation to the blood bacteremia. The maximal blood bacteremia that does not result in the appearance of bacteria in brain (red) and in CSF (green) is marked with a vertical line.