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. 2014 Nov 6;9(11):e112336. doi: 10.1371/journal.pone.0112336

Table 1. The association of DACT2 methylation and clinical factors in 99 cases of papillary thyroid cancer.

DACT2 methylation status
Clinical Factor No. methylated unmethylated p value
n = 64(64.6%) n = 35(35.4%) (χ2 test)
Age(years)
<46 56 39 17 0.235
≥46 43 25 18
Gender
Male 28 17 11 0.607
Female 71 47 24
Tumor Size(cm)
≤1 33 21 12 0.882
>1 66 43 23
Lymph Node Metastasis
Negative 50 25 25 0.002**
Positive 49 39 10

DACT2 methylation is associated with lymph node metastasis of papillary thyroid cancer (p = 0.002).

**p values are obtained from x2 test, significant difference, p<0.01.