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. 2014 Nov 4;107(9):2214–2220. doi: 10.1016/j.bpj.2014.09.017

Figure 1.

Figure 1

Different sources of noise in gene expression. Transcriptional bursting of mRNAs generates considerable intercellular variability in protein level. Additional variability (extrinsic noise) arises from fluctuations in transcription/translation rates. Total noise in protein level (CVp2), measured by the coefficient of variation (CV) squared, is decomposed into intrinsic and extrinsic noise (see text for details). To see this figure in color, go online.