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(A and B) Kinetic reaction schemes of the two tiers of the p38 MAPK module. Kinetically significant reactions and intermediates are displayed. (Shaded lines) Disfavored reaction pathways. (Dashes) Complexes; (pluses) reactants. (Underlined letters) Residues in the active site of the phosphorylating kinase in the complex. (Asterisks) Phosphorylation. Constants are shown in Table 1.
