Effects of hydroxynaphthoquinone mixture on pathological injury. A: Intestinal histopathological features; B: Pathological scores of colonic samples of each group. Colitis was induced by administration with 3.5% dextran sulfate sodium (DSS) for 6 d (original magnification, × 100). Hydroxynaphthoquinone mixture (HM) (3.5, 7, 14 mg/kg) or mesalazine 200 mg/kg was administered daily for 7 d. 1: Control; 2: Mice treated with DSS alone; 3: Mice treated with DSS plus mesalazine; 4-6: Mice treated with DSS plus HM (3.5, 7, 14 mg/kg respectively). Data are presented as mean ± SD (n = 8-10 mice). bP < 0.01 vs control; cP < 0.05 vs DSS alone.