FIGURE 4.

Aggregation kinetics of Aβ peptides measured by ThT fluorescence. A–C, process of Aβ aggregation was monitored over time using synthetic WT, A2T, or A2V Aβ peptides of pure Aβ(1–40) (A), pure Aβ(1–42) (B), or a 1:9 ratio of Aβ(1–42) to Aβ(1–40) (C). Mixtures of WT, A2T, and A2V are one-to-one molar ratios. Three separate experiments are shown for each set of peptides. Traces represent the mean of three replicate measurements, with ± S.D. shown for the final point. a.u., arbitrary units.