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Prevention of nucleation pathways by the chaperone DNAJB6. Schematic diagram showing (A) the molecular pathways involved in Aβ42 aggregation and (B) the proposed mechanism by which DNAJB6 inhibits the aggregation reaction. As indicated in faded colors in B, the interactions between the chaperone and the Aβ42 growing aggregates inhibit both primary (as seen in Fig. 3A) and secondary (as seen in Fig. 3F) nucleation pathways.
