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. 2014 Sep 24;289(45):31111–31120. doi: 10.1074/jbc.M114.600320

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 8. — Paclitaxel causes NKCC1 subcellular redistribution in the spinal cord through increased dynein activity. A, original blot images and quantification of NKCC1 protein levels in the plasma membrane and cytosolic fractions of spinal cord slices treated with vehicle (Ctrl, 0.1% DMSO) or ciliobrevin D (CBD, 50 μm) for 3 h. n = 6 rats in each group. B, original gel images and quantification of NKCC1 protein levels in the plasma membrane and cytosolic fractions of spinal cord slices treated with DMSO plus vehicle (Cremophor EL/ethanol), paclitaxel (PCX, 10 μm) plus ciliobrevin D, or PCX plus DMSO for 3 h. n = 6 rats in each group. C, original blot images and quantification of NKCC1 protein levels in the plasma membrane and cytosolic fractions of spinal cord slices with vehicle (Ctrl, 0.1% DMSO) or ispinesib (ISP, 1 μm). * p < 0.05; ** p < 0.01, compared with the vehicle control group. Error bars represent the S.E.