TABLE 2.
Analysis of gene expression in NSPCs from Tg2576 using a mouse neurogenesis and neural stem cell PCR array
Mouse PCR neurogenesis array results showing the expression of genes in Tg2576 NSPCs that are significantly up-regulated or down-regulated relative to NSPCs from the corresponding background strain WT mice. RNA was extracted from NSPC cultures derived from three independent mouse cohorts. Analysis and presentation of the data is the same as Table 1.
| Gene name | Expression level (relative to β-actin) |
-Fold up- or down- regulation in Tg | |
|---|---|---|---|
| Tg2576 | WT | ||
| Bone morphogenetic protein 4 | 3.1 × 10−3 | 6.4 × 10−3 | −2.05 |
| Bone morphogenetic protein 8 | 1.9 × 10−6 | 4.0 × 10−6 | −2.07 |
| CDK5 regulatory subunit associated protein 2 | 4.6 × 10−4 | 1.7 × 10−4 | 2.76 |
| Chemokine (C-X-C motif) ligand1 | 1.0 × 10−5 | 3.4 × 10−5 | −3.40 |
| Dopamine receptor D2 | 1.5 × 10−5 | 1.1 × 10−6 | 13.24 |
| Filamin, α | 1.9 × 10−3 | 7.7 × 10−4 | 2.41 |
| Glial cell line-derived neurotrophic factor | 1.8 × 10−4 | 5.1 × 10−5 | 3.46 |
| Hairy and enhancer of split1 | 1.1 × 10−4 | 3.9 × 10−4 | −3.42 |
| Hairy/enhancer-of-split related with YRPW motif1 | 2.6 × 10−5 | 8.7 × 10−6 | 3.00 |
| Myocyte enhancer factor 2C | 2.6 × 10−3 | 8.8 × 10−5 | 29.24 |
| Neurogenic differentiation 1 | 5.5 × 10−5 | 1.1 × 10−4 | −2.05 |
| Neurogenin 1 | 8.4 × 10−7 | 2.5 × 10−7 | 3.33 |
| Neurogenin 2 | 1.1 × 10−4 | 4.5 × 10−5 | 2.43 |
| Noggin | 3.4 × 10−4 | 5.8 × 10−5 | 5.92 |
| Nuclear receptor subfamily 2, group E, member 3 | 7.6 × 10−5 | 3.9 × 10−6 | 19.45 |
| POU domain, class 4, transcription factor 1 | 1.1 × 10−5 | 5.7 × 10−4 | −51.63 |
| Slit homolog 2 | 1.5 × 10−4 | 6.3 × 10−5 | 2.35 |