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Effects of depletion of K-Ras, RalA, and RalB on cell cycle progression. A549 cells were treated with indicated siRNAs for 48 h and processed for cell cycle analysis as described under “Experimental Procedures.” The percentage of cells in each cell cycle phase relative to nontargeting (NT) is shown. A, depletion of p53 rescue. B, depletion of p21 rescue.
